Tumor Microenvironment

Project Description

Single Cell Sequencing Technology for Elucidating the Tumor Microenvironment in Prostate Cancer

Is it possible to develop a vaccine that would help patients develop an immune response to prosate cancer? That is the goal of this study.

Our approach is to study the various kinds of cells that are found in the immediate region of a cancer tumor. Some of these are "immune cells" that are unaffected by cancer. A detailed genomic analysis of the immune cells helps us understand how their molecular "signature" protects them from cancer.

Once the molecular "signature" of the immune cells is known, we will translate this knowledge to develop vaccine-based immunotherapy. Then we can test whether a vaccine-based immunotherapy approach is truly effective. This study could also help in development of a personalized vaccine therapy-that is, a vaccine that is particularly effective with individual patients based on the "molecular class" of their tumor.

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Tumor Microenvironment

Tumor Microenvironment

Is it possible to develop a vaccine that would help patients develop an immune response to prosate cancer?
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Radio Hystopathological Correlation

The potential role of prostate MRI has in recent years expanded significantly, and there is great hope that mpMRI can help address two major problems encountered when treating prostate cancer.
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Poly-ICLC

Poly-ICLC Prostate Cancer Vaccine
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Primary Cell Cultures Care

Primary Cell Cultures as Models of Prostate Cancer Development
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Inflammation & Prostate Cancer

Inflammation and its impact on Prostate Cancer Aggressiveness
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GU Immunotherapy

GU Immunotherapy

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